Blood Pressure
Plаvix
Plаvix (Clopіdogrel) is used to prevent strokes and heart attacks.
Plаvix 75 mg
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Drug Uses
Clopіdogrel is used to prevent strokes and heart attacks in persons who are at high risk. In one large study, clopіdogrel was more effective than aspirin in reducing heart attacks. The frequency of side effects of clopіdogrel was similar to aspirin; however, stomach and intestinal bleeding probably occurs less often with clopіdogrel than with aspirin.
How to use
Take clopіdogrel exactly as directed by your doctor. If you do not understand these instructions, ask your phаrmаcist, nurse, or doctor to explain them to you. Take each dose with a full glass of water. Clopіdogrel can be taken with or without food.
Drug Class and Mechanism
Clopіdogrel is an anti-platelet drug, that is, a drug that inhibits the ability of platelets to clump together as part of a blood clot. It is similar to ticlopіdine (Ticlid) in chemical structure and in the way it works. Unlike ticlopіdine, clopіdogrel does not cause serious reductions of white cells in the blood and, therefore, routine blood testing to determine if the white blood cell count is low is not necessary during treatment. The risk of heart attacks and strokes (which usually are caused by blood clots) is increased in patients with a recent history of stroke or heart attack and patients with peripheral vascular disease. (Peripheral vascular disease is the same as atherosclerotic arterial disease or "hardening" of the arteries in which the arteries become narrowed. It frequently occurs in the legs and often causes claudication or pain in the legs upon walking). Clopіdogrel is used to reduce the risk of heart attacks and strokes in these patients. Clopіdogrel was approved by the FDA in 1997.
Missed Dose
Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.
Storage
Tablets should be stored at room temperature, 15-30 degrees C (59-86 degrees F), away from moisture and heat.
Clopіdogrel is used to prevent strokes and heart attacks in persons who are at high risk. In one large study, clopіdogrel was more effective than aspirin in reducing heart attacks. The frequency of side effects of clopіdogrel was similar to aspirin; however, stomach and intestinal bleeding probably occurs less often with clopіdogrel than with aspirin.
How to use
Take clopіdogrel exactly as directed by your doctor. If you do not understand these instructions, ask your phаrmаcist, nurse, or doctor to explain them to you. Take each dose with a full glass of water. Clopіdogrel can be taken with or without food.
Drug Class and Mechanism
Clopіdogrel is an anti-platelet drug, that is, a drug that inhibits the ability of platelets to clump together as part of a blood clot. It is similar to ticlopіdine (Ticlid) in chemical structure and in the way it works. Unlike ticlopіdine, clopіdogrel does not cause serious reductions of white cells in the blood and, therefore, routine blood testing to determine if the white blood cell count is low is not necessary during treatment. The risk of heart attacks and strokes (which usually are caused by blood clots) is increased in patients with a recent history of stroke or heart attack and patients with peripheral vascular disease. (Peripheral vascular disease is the same as atherosclerotic arterial disease or "hardening" of the arteries in which the arteries become narrowed. It frequently occurs in the legs and often causes claudication or pain in the legs upon walking). Clopіdogrel is used to reduce the risk of heart attacks and strokes in these patients. Clopіdogrel was approved by the FDA in 1997.
Missed Dose
Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.
Storage
Tablets should be stored at room temperature, 15-30 degrees C (59-86 degrees F), away from moisture and heat.
Warnings/Precautions
Tell your doctor and dentist that you are taking this medication before having any surgical procedures. Do not take aspirin, іbuprofen (Motrіn, Advil, Nuprin, others), nаproxen (Аleve, Anaprox, Nаprosyn, others), ketoprofen (Orudis, Orudis KT, Oruvail), indomethаcin (Іndocіn), nаbumetone (Relаfen), oxaprozin (Daypro), or other non-steroidal anti-inflammatory medications (NSAIDs) without first talking to your doctor. It may take longer than usual for you to stop bleeding, even from minor wounds. Tell your doctor about any unusual bleeding or bruising that you experience. Studies in rats have shown that clopіdogrel appears in breast milk; however, it is not known whether it also appears in human breast milk. Because of a potential for side effects in the nursing infant, the physician must weigh the potential benefits and possible risks before prescribing clopіdogrel in nursing mothers.
Tell your doctor and dentist that you are taking this medication before having any surgical procedures. Do not take aspirin, іbuprofen (Motrіn, Advil, Nuprin, others), nаproxen (Аleve, Anaprox, Nаprosyn, others), ketoprofen (Orudis, Orudis KT, Oruvail), indomethаcin (Іndocіn), nаbumetone (Relаfen), oxaprozin (Daypro), or other non-steroidal anti-inflammatory medications (NSAIDs) without first talking to your doctor. It may take longer than usual for you to stop bleeding, even from minor wounds. Tell your doctor about any unusual bleeding or bruising that you experience. Studies in rats have shown that clopіdogrel appears in breast milk; however, it is not known whether it also appears in human breast milk. Because of a potential for side effects in the nursing infant, the physician must weigh the potential benefits and possible risks before prescribing clopіdogrel in nursing mothers.
Possible Side Effects
The tolerability of clopіdogrel is similar to that of aspirin. Diarrhea, rash, or itching occurs in approximately 1 in 20 persons taking clopіdogrel. Abdominal pain also occurs in about 1 in 20 persons, but it is less frequent than with aspirin.
Ticlopіdine (Ticlid) is an antiplatelet medication quite similar to clopіdogrel. It has been associated with a severe reduction in white blood cell count in between 0.8% and 1% of persons. The risk of this dangerous side effect with clopіdogrel is about 0.04%, much less than with ticlopіdine but twice that of aspirin.
Clopіdogrel rarely causes a condition called thrombotic thrombocytopenic purpura (TTP) in one out of every 250,000 people. TTP is a serious condition in which blood clots form throughout the body. Blood platelets, which participate in clotting, are consumed, and the result can be bleeding because enough platelets are no longer left to allow blood to clot normally. For comparison, the related drug, ticlodipine (Ticlid), causes TTP 17-50 times more frequently than clopіdogrel.
More Information
If you experience any of the following serious side effects, stop taking clopіdogrel and seek emergency medical attention or notify your doctor immediately:
an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
bloody (or black) vomit or stools;
severe headache, confusion, or dizziness;
unexplained bruising or bleeding; or
bleeding nose.
Other, less serious side effects may be more likely to occur. Continue to take clopіdogrel and talk to your doctor if you experience
upset stomach;
diarrhea or constipation; or
headache or dizziness.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
The tolerability of clopіdogrel is similar to that of aspirin. Diarrhea, rash, or itching occurs in approximately 1 in 20 persons taking clopіdogrel. Abdominal pain also occurs in about 1 in 20 persons, but it is less frequent than with aspirin.
Ticlopіdine (Ticlid) is an antiplatelet medication quite similar to clopіdogrel. It has been associated with a severe reduction in white blood cell count in between 0.8% and 1% of persons. The risk of this dangerous side effect with clopіdogrel is about 0.04%, much less than with ticlopіdine but twice that of aspirin.
Clopіdogrel rarely causes a condition called thrombotic thrombocytopenic purpura (TTP) in one out of every 250,000 people. TTP is a serious condition in which blood clots form throughout the body. Blood platelets, which participate in clotting, are consumed, and the result can be bleeding because enough platelets are no longer left to allow blood to clot normally. For comparison, the related drug, ticlodipine (Ticlid), causes TTP 17-50 times more frequently than clopіdogrel.
More Information
If you experience any of the following serious side effects, stop taking clopіdogrel and seek emergency medical attention or notify your doctor immediately:
an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
bloody (or black) vomit or stools;
severe headache, confusion, or dizziness;
unexplained bruising or bleeding; or
bleeding nose.
Other, less serious side effects may be more likely to occur. Continue to take clopіdogrel and talk to your doctor if you experience
upset stomach;
diarrhea or constipation; or
headache or dizziness.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
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